Aging as “Time-Related Dysfunction”: A Perspective

Podocyte dysfunction in aging--related glomerulosclerosis.

We review podocyte molecular structure and function, consider the underlying mechanisms related to podocyte dysfunction and propose that podocyte dysfunction be considered in the evaluation and management of age-associated glomerulosclerosis. With aging, progressive sympathetic activation, increased intrarenal renin-angiotensin system (RAS) activity, endothelin system and oxidative stress and r...

An Epigenetic Hypothesis of Aging-Related Cognitive Dysfunction

This brief review will focus on a new hypothesis for the role of epigenetic mechanisms in aging-related disruptions of synaptic plasticity and memory. Epigenetics refers to a set of potentially self-perpetuating, covalent modifications of DNA and post-translational modifications of nuclear proteins that produce lasting alterations in chromatin structure. These mechanisms, in turn, result in alt...

Time Perspective and Emotion Regulation as Predictors of Age-Related Subjective Passage of Time

Hardly any empirical work exists concerning the relationship between the intra-individually stable time perspective relating to the past, present, and future and the subjective speed of time passing in everyday life. Moreover, studies consistently show that the subjective passage of time over the period of the last ten years speeds up as we get older. Modulating variables influencing this pheno...

A new perspective on the determinants of the concept of aging: a letter to the editor

Bayesian perspective over time

Thomas Bayes, the founder of Bayesian vision, entered the University of Edinburgh in 1719 to study logic and theology. Returning in 1722, he worked with his father in a small church. He also was a mathematician and in 1740 he made a novel discovery which he never published, but his friend Richard Price found it in his notes after his death in 1761, reedited it and published it. But until L...